Cyclopropanecarbonyl chloride → N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-2-(cyclopropanecarboxamido)oxazole-5-carboxamide
Reaction equation
[NH2:1][C:2]1[O:3][C:4]([C:7]([NH:9][CH:10]([C:12]2[CH:13]=[N:14][C:15]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[C:16]([Cl:18])[CH:17]=2)[CH3:11])=[O:8])=[CH:5][N:6]=1.[CH:25]1([C:28](Cl)=[O:29])[CH2:27][CH2:26]1>>[Cl:18][C:16]1[CH:17]=[C:12]([CH:10]([NH:9][C:7]([C:4]2[O:3][C:2]([NH:1][C:28]([CH:25]3[CH2:27][CH2:26]3)=[O:29])=[N:6][CH:5]=2)=[O:8])[CH3:11])[CH:13]=[N:14][C:15]=1[O:19][CH2:20][C:21]([F:23])([F:22])[F:24]Participants
3
Procedure
The title compound is prepared from 2-amino-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)oxazole-5-carboxamide (30 mg, 0.08 mmol, Step-1, single enantiomer) and cyclopropanecarbonyl chloride (13 mg, 0.12 mmol) according to the procedure similar to that described in Step-2 of Example 8.
Sources & evidence
- ORD record
- ord-074a105ceb5c4da6ba05c2d18a4bc59c
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09302991B2
Reaction notes
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