Cyclopropanecarbonyl chloride → 6-(cyclopropanecarboxamido)-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide

HRID 623588Notes

Reaction equation

HRID 623588 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][CH:11]([C:13]2[CH:14]=[N:15][C:16]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[CH:17][CH:18]=2)[CH3:12])=[O:9])[CH:3]=1.[CH:25]1([C:28](Cl)=[O:29])[CH2:27][CH2:26]1>>[CH:25]1([C:28]([NH:1][C:2]2[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][CH:11]([C:13]3[CH:14]=[N:15][C:16]([O:19][CH2:20][C:21]([F:23])([F:22])[F:24])=[CH:17][CH:18]=3)[CH3:12])=[O:9])[CH:3]=2)=[O:29])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 675109706-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide

Product 1

HCID 675108636-(cyclopropanecarboxamido)-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide

Procedure

The title compound is prepared from 6-amino-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)pyrimidine-4-carboxamide (30 mg, 0.09 mmol, Step-1 of Example 117, single enantiomer) and cyclopropanecarbonyl chloride (14 mg, 0.13 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Sources & evidence

ORD record
ord-ccced22238de4e0ba8c4e336329a7037
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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