2-Aminopyrimidine-4-carboxylic acid → HCID 67509939, compound

HRID 623591Notes

Reaction equation

HRID 623591 reaction equation
Cl.[F:2][C:3]([F:17])([F:16])[CH2:4][CH2:5][O:6][C:7]1[N:12]=[CH:11][C:10]([CH:13]([NH2:15])[CH3:14])=[CH:9][CH:8]=1.[NH2:18][C:19]1[N:24]=[C:23]([C:25](O)=[O:26])[CH:22]=[CH:21][N:20]=1>>[NH2:18][C:19]1[N:24]=[C:23]([C:25]([NH:15][CH:13]([C:10]2[CH:11]=[N:12][C:7]([O:6][CH2:5][CH2:4][C:3]([F:2])([F:16])[F:17])=[CH:8][CH:9]=2)[CH3:14])=[O:26])[CH:22]=[CH:21][N:20]=1

Participants

3

Reactant 2

HCID 2471942-Aminopyrimidine-4-carboxylic acidHCID 675093381-(6-(3,3,3-Trifluoropropoxy)pyridin-3-yl)ethanamine hydrochloride

Product 1

HCID 67509939HCID 67509939, compoundYield 64%

Procedure

The title compound is prepared in 64% yield (100 mg, a white solid) from 1-(6-(3,3,3-trifluoropropoxy)pyridin-3-yl)ethanamine hydrochloride (120 mg, 0.4 mmol, Amine-21, single enantiomer) and 2-aminopyrimidine-4-carboxylic acid (62 mg, 0.4 mmol) by the similar manner in Step-1 of Example 8.

Sources & evidence

ORD record
ord-b09dd97d460e49308f6181d1e750d774
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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