Propionyl chloride → (R)-2-propionamido-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide

HRID 623617Notes

Reaction equation

HRID 623617 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][C@@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1.[C:23](Cl)(=[O:26])[CH2:24][CH3:25]>>[C:23]([NH:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][C@@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:20])[F:21])[CH:14]=2)[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1)(=[O:26])[CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 62324Propionyl chlorideHCID 67510410(R)-2-amino-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide

Product 1

HCID 67508804(R)-2-propionamido-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide

Procedure

The title compound is prepared from (R)-2-amino-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide (20 mg, 0.06 mmol, Step-1) and propionyl chloride (18 mg, 0.19 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Sources & evidence

ORD record
ord-ea9fab013df745ea8af9245b8cc71a0a
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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