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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623617Generated: October 31, 2026

Propionyl chloride → (R)-2-propionamido-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide

https://huagongshe.com/reaction/623617

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPropionyl chlorideHCID 62324—
Reactant(R)-2-amino-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamideHCID 67510410—
Product(R)-2-propionamido-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamideHCID 67508804—

Reaction Steps

The title compound is prepared from (R)-2-amino-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide (20 mg, 0.06 mmol, Step-1) and propionyl chloride (18 mg, 0.19 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-ea9fab013df745ea8af9245b8cc71a0a
Source noteuspto-grants-2016_04