3-(Trifluoromethoxy)benzylamine → 2-amino-N-(3-(trifluoromethoxy)benzyl)pyrimidine-4-carboxamide

HRID 623618Notes

Reaction equation

HRID 623618 reaction equation
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH2:10][NH2:11])[CH:7]=[CH:8][CH:9]=1.[NH2:14][C:15]1[N:20]=[C:19]([C:21](O)=[O:22])[CH:18]=[CH:17][N:16]=1>>[NH2:14][C:15]1[N:20]=[C:19]([C:21]([NH:11][CH2:10][C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:12])([F:13])[F:1])[CH:5]=2)=[O:22])[CH:18]=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 1452643-(Trifluoromethoxy)benzylamineHCID 2471942-Aminopyrimidine-4-carboxylic acid

Product 1

HCID 675097342-amino-N-(3-(trifluoromethoxy)benzyl)pyrimidine-4-carboxamideYield 37%

Procedure

The title compound is prepared in 37% yield (82 mg, a white solid) from (3-(trifluoromethoxy)phenyl)methanamine (137 mg, 0.72 mmol) and 2-aminopyrimidine-4-carboxylic acid (100 mg, 0.72 mmol) by the similar manner in Step-1 of Example 8.

Sources & evidence

ORD record
ord-02c261dd82be48819c5832fecb65dd70
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

Loading…