HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethoxy)benzylamine → 2-amino-N-(3-(trifluoromethoxy)benzyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethoxy)benzylamine | HCID 145264 | — |
| Reactant | 2-Aminopyrimidine-4-carboxylic acid | HCID 247194 | — |
| Product | 2-amino-N-(3-(trifluoromethoxy)benzyl)pyrimidine-4-carboxamide | HCID 67509734 | 37% |
Reaction Steps
The title compound is prepared in 37% yield (82 mg, a white solid) from (3-(trifluoromethoxy)phenyl)methanamine (137 mg, 0.72 mmol) and 2-aminopyrimidine-4-carboxylic acid (100 mg, 0.72 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-02c261dd82be48819c5832fecb65dd70 |
| Source note | uspto-grants-2016_04 |