2-Aminopyrimidine-4-carboxylic acid → 2-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide

HRID 623623Notes

Reaction equation

HRID 623623 reaction equation
Cl.[F:2][C:3]([F:15])([F:14])[CH2:4][O:5][C:6]1[N:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][CH:7]=1.[NH2:16][C:17]1[N:22]=[C:21]([C:23](O)=[O:24])[CH:20]=[CH:19][N:18]=1>>[NH2:16][C:17]1[N:22]=[C:21]([C:23]([NH:13][CH2:12][C:9]2[CH:10]=[N:11][C:6]([O:5][CH2:4][C:3]([F:2])([F:14])[F:15])=[CH:7][CH:8]=2)=[O:24])[CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 2471942-Aminopyrimidine-4-carboxylic acidHCID 67508831(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride

Product 1

HCID 675100572-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamideYield 22%

Procedure

The title compound is prepared in 22% yield (42 mg, a white solid) from (6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (140 mg, 0.58 mmol) and 2-aminopyrimidine-4-carboxylic acid (80 mg, 0.58 mmol) by the similar manner in Step-1 of Example 8.

Sources & evidence

ORD record
ord-b08f0b3983d84b27a16600229e4c68dc
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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