HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyrimidine-4-carboxylic acid → 2-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyrimidine-4-carboxylic acid | HCID 247194 | — |
| Reactant | (6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride | HCID 67508831 | — |
| Product | 2-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide | HCID 67510057 | 22% |
Reaction Steps
The title compound is prepared in 22% yield (42 mg, a white solid) from (6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (140 mg, 0.58 mmol) and 2-aminopyrimidine-4-carboxylic acid (80 mg, 0.58 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-b08f0b3983d84b27a16600229e4c68dc |
| Source note | uspto-grants-2016_04 |