Isobutyryl chloride → 2-isobutyramido-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide

HRID 623624Notes

Reaction equation

HRID 623624 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][C:15]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[CH:16][CH:17]=2)=[O:9])[CH:5]=[CH:4][N:3]=1.[C:24](Cl)(=[O:28])[CH:25]([CH3:27])[CH3:26]>>[C:24]([NH:1][C:2]1[N:7]=[C:6]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][C:15]([O:18][CH2:19][C:20]([F:22])([F:23])[F:21])=[CH:16][CH:17]=2)=[O:9])[CH:5]=[CH:4][N:3]=1)(=[O:28])[CH:25]([CH3:27])[CH3:26]

Participants

3

Reactant 2

HCID 62325Isobutyryl chlorideHCID 675100572-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide

Product 1

HCID 675095332-isobutyramido-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide

Procedure

The title compound is prepared from 2-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide (17 mg, 0.05 mmol, Step-1) and isobutyryl chloride (17 mg, 0.16 mmol) according to the procedure similar to that described in Step-2 of Example 8.

Sources & evidence

ORD record
ord-5fa9187f33824cb286452973aeb75508
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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