Cyclobutanecarbonyl chloride → 2-(cyclobutanecarboxamido)-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide

HRID 623636Notes

Reaction equation

HRID 623636 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:22]=[C:23]([CH3:25])[N:24]=1)[C:5]([NH:7][CH:8]([C:10]1[CH:11]=[N:12][C:13]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:14][CH:15]=1)[CH3:9])=[O:6].[CH:26]1([C:30](Cl)=[O:31])[CH2:29][CH2:28][CH2:27]1>>[CH:26]1([C:30]([NH:1][C:2]2[CH:3]=[C:4]([CH:22]=[C:23]([CH3:25])[N:24]=2)[C:5]([NH:7][CH:8]([C:10]2[CH:11]=[N:12][C:13]([O:16][CH2:17][C:18]([F:21])([F:19])[F:20])=[CH:14][CH:15]=2)[CH3:9])=[O:6])=[O:31])[CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 78705Cyclobutanecarbonyl chlorideHCID 675112252-amino-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide

Product 1

HCID 675090432-(cyclobutanecarboxamido)-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide

Procedure

The title compound is prepared from 2-amino-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide (Step-1, single enantiomer) and cyclobutanecarbonyl chloride according to the procedure similar to that described in Step-2 of Example 8.

Sources & evidence

ORD record
ord-cfdeee9a4a61445384bdcf7b1590e27b
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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