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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623636Generated: October 30, 2026

Cyclobutanecarbonyl chloride → 2-(cyclobutanecarboxamido)-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide

https://huagongshe.com/reaction/623636

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclobutanecarbonyl chlorideHCID 78705—
Reactant2-amino-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamideHCID 67511225—
Product2-(cyclobutanecarboxamido)-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamideHCID 67509043—

Reaction Steps

The title compound is prepared from 2-amino-6-methyl-N-(1-(6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)isonicotinamide (Step-1, single enantiomer) and cyclobutanecarbonyl chloride according to the procedure similar to that described in Step-2 of Example 8.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-cfdeee9a4a61445384bdcf7b1590e27b
Source noteuspto-grants-2016_04