2-(Methoxycarbonyl)-6-methylisonicotinic acid → Methyl 4-((1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)-6-methylpicolinate

HRID 623642Notes

Reaction equation

HRID 623642 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:15]([NH2:17])[CH3:16])[CH:6]=[N:7][C:8]=1[O:9][CH2:10][C:11]([F:14])([F:13])[F:12].[CH3:18][O:19][C:20]([C:22]1[CH:23]=[C:24]([CH:28]=[C:29]([CH3:31])[N:30]=1)[C:25](O)=[O:26])=[O:21]>>[Cl:2][C:3]1[CH:4]=[C:5]([CH:15]([NH:17][C:25]([C:24]2[CH:28]=[C:29]([CH3:31])[N:30]=[C:22]([C:20]([O:19][CH3:18])=[O:21])[CH:23]=2)=[O:26])[CH3:16])[CH:6]=[N:7][C:8]=1[O:9][CH2:10][C:11]([F:12])([F:13])[F:14]

Participants

3

Reactant 2

HCID 595708792-(Methoxycarbonyl)-6-methylisonicotinic acidHCID 675090891-(5-Chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride

Product 1

HCID 67508828Methyl 4-((1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)-6-methylpicolinate

Procedure

The title compound is prepared from (+)-1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (Amine-5, single enantiomer) and 2-(methoxycarbonyl)-6-methylisonicotinic acid by the similar manner in Step-1 of Example 8.

Sources & evidence

ORD record
ord-02eba80c78ad4de18b9d2ff473742e67
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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