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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623642Generated: October 29, 2026

2-(Methoxycarbonyl)-6-methylisonicotinic acid → Methyl 4-((1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)-6-methylpicolinate

https://huagongshe.com/reaction/623642

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Methoxycarbonyl)-6-methylisonicotinic acidHCID 59570879—
Reactant1-(5-Chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochlorideHCID 67509089—
ProductMethyl 4-((1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)carbamoyl)-6-methylpicolinateHCID 67508828—

Reaction Steps

The title compound is prepared from (+)-1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (Amine-5, single enantiomer) and 2-(methoxycarbonyl)-6-methylisonicotinic acid by the similar manner in Step-1 of Example 8.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-02eba80c78ad4de18b9d2ff473742e67
Source noteuspto-grants-2016_04