(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride → 2-methyl-6-pivalamido-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isonicotinamide
Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([NH:11][C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[N:10]=1)[C:5]([OH:7])=O.Cl.[F:19][C:20]([F:32])([F:31])[CH2:21][O:22][C:23]1[N:28]=[CH:27][C:26]([CH2:29][NH2:30])=[CH:25][CH:24]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([NH:11][C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[N:10]=1)[C:5]([NH:30][CH2:29][C:26]1[CH:27]=[N:28][C:23]([O:22][CH2:21][C:20]([F:32])([F:19])[F:31])=[CH:24][CH:25]=1)=[O:7]Participants
3
Procedure
The title compound is prepared from 2-methyl-6-pivalamidoisonicotinic acid (30 mg, 0.06 mmol, Step-1) and (6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (15 mg, 0.06 mmol) by the similar manner in Example 2.
Sources & evidence
- ORD record
- ord-2873837edb2443cdb00710a80433b37b
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09302991B2
Reaction notes
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