2-Aminooxazole → HCID 67508555, compound

HRID 623648Notes

Reaction equation

HRID 623648 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[C:4]([CH3:12])[N:3]=1.[O:13]1[CH:17]=[CH:16][N:15]=[C:14]1[NH2:18]>>[CH3:12][C:4]1[N:3]=[C:2]([NH:18][C:14]2[O:13][CH:17]=[CH:16][N:15]=2)[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=1

Participants

3

Reactant 2

HCID 5585212-AminooxazoleHCID 2736835Methyl 2-chloro-6-methylpyrimidine-4-carboxylate

Product 1

HCID 67508555HCID 67508555, compoundYield 22%

Procedure

The title compound is prepared in 22% yield (83 mg, a pale yellow solid) from methyl 2-chloro-6-methylpyrimidine-4-carboxylate (300 mg, 1.6 mmol) and oxazol-2-amine (200 mg, 2.4 mmol) by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record
ord-4890cb0f6ff04dbb96d9cdfc09829d85
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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