(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride → 6-methyl-2-(oxazol-2-ylamino)-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide

HRID 623649Notes

Reaction equation

HRID 623649 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[O:10][CH:11]=[CH:12][N:13]=2)[N:5]=[C:4]([C:14]([OH:16])=O)[CH:3]=1.Cl.[F:18][C:19]([F:31])([F:30])[CH2:20][O:21][C:22]1[N:27]=[CH:26][C:25]([CH2:28][NH2:29])=[CH:24][CH:23]=1>>[CH3:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[O:10][CH:11]=[CH:12][N:13]=2)[N:5]=[C:4]([C:14]([NH:29][CH2:28][C:25]2[CH:26]=[N:27][C:22]([O:21][CH2:20][C:19]([F:31])([F:18])[F:30])=[CH:23][CH:24]=2)=[O:16])[CH:3]=1

Participants

3

Reactant 2

HCID 67508831(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)methanamine hydrochlorideHCID 675095226-Methyl-2-(oxazol-2-ylamino)pyrimidine-4-carboxylic acid

Product 1

HCID 675098076-methyl-2-(oxazol-2-ylamino)-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide

Procedure

The title compound is prepared from 6-methyl-2-(oxazol-2-ylamino)pyrimidine-4-carboxylic acid (25 mg, 0.11 mmol, Step-1) and (6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (28 mg, 0.11 mmol) by the similar manner in Example-2.

Sources & evidence

ORD record
ord-3d7f2b2bd599460ea7242ec3fc99fe3e
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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