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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623649Generated: October 26, 2026

(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride → 6-methyl-2-(oxazol-2-ylamino)-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamide

https://huagongshe.com/reaction/623649

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(6-(2,2,2-Trifluoroethoxy)pyridin-3-yl)methanamine hydrochlorideHCID 67508831—
Reactant6-Methyl-2-(oxazol-2-ylamino)pyrimidine-4-carboxylic acidHCID 67509522—
Product6-methyl-2-(oxazol-2-ylamino)-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)pyrimidine-4-carboxamideHCID 67509807—

Reaction Steps

The title compound is prepared from 6-methyl-2-(oxazol-2-ylamino)pyrimidine-4-carboxylic acid (25 mg, 0.11 mmol, Step-1) and (6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (28 mg, 0.11 mmol) by the similar manner in Example-2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302991B2
Source datasetuspto-grants-2016_04
ORD IDord-3d7f2b2bd599460ea7242ec3fc99fe3e
Source noteuspto-grants-2016_04