2-(Methoxycarbonyl)-6-methylisonicotinic acid → Methyl 4-(((2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)carbamoyl)-6-methylpicolinate

HRID 623650Notes

Reaction equation

HRID 623650 reaction equation
Cl.[CH3:2][O:3][C:4]1[C:9]([CH2:10][NH2:11])=[CH:8][CH:7]=[C:6]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[N:5]=1.[CH3:18][O:19][C:20]([C:22]1[CH:23]=[C:24]([CH:28]=[C:29]([CH3:31])[N:30]=1)[C:25](O)=[O:26])=[O:21]>>[CH3:2][O:3][C:4]1[C:9]([CH2:10][NH:11][C:25]([C:24]2[CH:28]=[C:29]([CH3:31])[N:30]=[C:22]([C:20]([O:19][CH3:18])=[O:21])[CH:23]=2)=[O:26])=[CH:8][CH:7]=[C:6]([O:12][CH2:13][C:14]([F:17])([F:15])[F:16])[N:5]=1

Participants

3

Reactant 2

HCID 595708792-(Methoxycarbonyl)-6-methylisonicotinic acidHCID 67510493(2-Methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride

Product 1

HCID 67510315Methyl 4-(((2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)carbamoyl)-6-methylpicolinate

Procedure

The title compound is prepared from (2-methoxy-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (Amine-24) and 2-(methoxycarbonyl)-6-methylisonicotinic acid by the similar manner in Step-1 of Example 8.

Sources & evidence

ORD record
ord-cfbd5c1806754b428cc8a764411c7cb1
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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