1-[3-(Trifluoromethoxy)phenyl]ethan-1-amine → Methyl 6-methyl-4-((1-(3-(trifluoromethoxy)phenyl)ethyl)carbamoyl)picolinate

HRID 623651Notes

Reaction equation

HRID 623651 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:5]=[C:6]([CH:10]([NH2:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1.[CH3:15][O:16][C:17]([C:19]1[CH:20]=[C:21]([CH:25]=[C:26]([CH3:28])[N:27]=1)[C:22](O)=[O:23])=[O:18]>>[CH3:28][C:26]1[N:27]=[C:19]([C:17]([O:16][CH3:15])=[O:18])[CH:20]=[C:21]([C:22](=[O:23])[NH:12][CH:10]([C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:13])([F:14])[F:1])[CH:5]=2)[CH3:11])[CH:25]=1

Participants

3

Reactant 2

HCID 226055421-[3-(Trifluoromethoxy)phenyl]ethan-1-amineHCID 595708792-(Methoxycarbonyl)-6-methylisonicotinic acid

Product 1

HCID 67510274Methyl 6-methyl-4-((1-(3-(trifluoromethoxy)phenyl)ethyl)carbamoyl)picolinate

Procedure

The title compound is prepared from (+)-1-(3-(trifluoromethoxy)phenyl)ethanamine (Amine-9) and 2-(methoxycarbonyl)-6-methylisonicotinic acid by the similar manner in Step-1 of Example 8.

Sources & evidence

ORD record
ord-6321dac7a98f4d7e826a094c8444fb55
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Reaction notes

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