Methylamine → HCID 67509765, compound

HRID 623652Notes

Reaction equation

[CH3:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[CH:5]=[C:4]([C:11](=[O:26])[NH:12][CH:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]([F:25])([F:24])[F:23])[CH:16]=2)[CH3:14])[CH:3]=1.[CH3:27][NH2:28]>>[CH3:27][NH:28][C:8]([C:6]1[CH:5]=[C:4]([C:11]([NH:12][CH:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]([F:23])([F:25])[F:24])[CH:16]=2)[CH3:14])=[O:26])[CH:3]=[C:2]([CH3:1])[N:7]=1)=[O:10]

Participants

Reactant 2

HCID 6329Methylamine

HCID 67509859HCID 67509859, compound

Product 1

HCID 67509765HCID 67509765, compound

Procedure

The title compound is prepared from 6-methyl-4-((1-(3-(trifluoromethoxy)phenyl)ethyl)carbamoyl)picolinic acid (20 mg, 0.05 mmol, Step-2, single enantiomer) and methanamine (11 mg, 0.16 mmol) by the similar manner in Example-2.

Sources & evidence

ORD record: ord-684262e86d1749ef97773ce900118ec5
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302991B2

Reaction notes

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