HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetamidopyridine-4-carboxylic acid → 2-acetamido-N-((5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetamidopyridine-4-carboxylic acid | HCID 3774466 | — |
| Reactant | (5-Bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride | HCID 67508543 | — |
| Product | 2-acetamido-N-((5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isonicotinamide | HCID 67509687 | 61% |
Reaction Steps
The title compound is prepared in 61% yield (380 mg, a white solid) from (5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (450 mg, 1.4 mmol, Amine-67) and 2-acetamidoisonicotinic acid (250 mg, 1.4 mmol) by the similar manner in Step-1 of Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-084033b3d7b1465b96b67eba2c665c9c |
| Source note | uspto-grants-2016_04 |