[3-(2,4-dihydroxy-5-isopropyl-phenyl)-5-ethylcarbamoyl-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-phenyl)-carbamic acid tert-butyl ester → 1-(2,4-dihydroxy-5-isopropyl-phenyl)-5-(4-morpholin-4-yl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid ethylamide

Participants

Reaction Steps

A solution of the intermediate from Step D in DCM/TFA (1/1, 2 ml) was stirred for 12 hours at RT. The reaction mixture was concentrated under reduced pressure and the crude reaction mixture was purified by column chromatography (DCM/MeOH: 95/5). The title compound was obtained as a slightly brown solid.

Provenance & Evidence