反应详情

温度

23 °C

To a stirred solution of 4-methoxybenzyl chloride (25.0 g, 156 mmol) in N,N-dimethylformamide (75 mL) was added sodium azide (11.5 g, 177 mmol). The reaction mixture was stirred at 23° C. for 15 h, then diluted with water (300 mL). The mixture was extracted with diethyl ether (3×75 mL) and the combined organic layers were washed with water (2×100 mL). The organic layer was dried (MgSO4), filtered, and evaporated under reduced pressure to afford the title compound (25.5 g) as a pale yellow oil. The title compound was used directly in the next step without further purification.

1. extractionThe mixture was extracted with diethyl ether (3×75 mL)
2. washthe combined organic layers were washed with water (2×100 mL)
3. dry with materialThe organic layer was dried (MgSO4)
4. filtrationfiltered
5. customevaporated under reduced pressure