Triethylamine → HCID 86711859, compound

HRID 623774Notes

Reaction equation

HRID 623774 reaction equation
[CH2:1]([N:8]1[C:12]([C:13]([F:16])([F:15])[F:14])=[CH:11][C:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[C:9]1[C:24]([N:26]([CH2:28][C:29]([C:32](=[O:34])[NH2:33])([CH3:31])[CH3:30])[CH3:27])=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCN(CC)CC.C1C=CC(P([N:56]=[N+:57]=[N-])(C2C=CC=CC=2)=O)=CC=1>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[C:12]([C:13]([F:14])([F:15])[F:16])=[CH:11][C:10]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=2)=[C:9]1[C:24]([N:26]([CH2:28][C:29]([CH3:31])([CH3:30])[C:32]([N:33]=[N+:56]=[N-:57])=[O:34])[CH3:27])=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 86711860HCID 86711860, compound

Product 1

HCID 86711859HCID 86711859, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a stirred solution of 1-02 [see step 4 SC-174] (110 mg, 0.223 mmol) in dry toluene (4 mL) was added Et3N (62 μL, 0.446 mmol) and DPPA (63 μL, 0.290 mmol). The reaction mixture was stirred overnight and concentrated in vacuo to give the desired product as a yellow oil.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e74c83e0bef448c1a0eb029d38956461
Source dataset
uspto-grants-2016_04
Patent number
US09302988B2

Reaction notes

Loading…