Diisopropylethylamine → 3-(4-Chlorophenyl)-N-methyl-N-neopentyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxamide

Temperature

60 °C

N-Methyl neopentyl amine (0.781 g, 5.68 mmol) and 3-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid (1.37 g, 4.73 mmol) were combined in DME (13 mL). DIPEA (3.47 mL, 19.87 mmol) and BOP-CI (2.53 g, 9.93 mmol) were added. The mixture was stirred at 60° C. for 1 h. The reaction mixture was diluted with EtOAc (50 mL) and washed with aqueous 1M KHSO4 (3×20 mL), aqueous saturated NaHCO3 (3×20 mL) and brine (2×20 mL) before drying on Na2SO4 and concentration in vacuo to give an oil. The product was dissolved by heating in i-Pr2O and left to cool for 16 h. A solid had formed which was filtered off and washed with i-Pr2O (2×5 mL) to give a light yellow solid. The filtrate was combined with the residue and purified using column chromatography (silica, gradient heptane/EtOAc 95:5−>7:3) to give the desired product (604 mg, 34%) as a yellow solid. The mother liquor was concentrated in vacuo and triturated with heptane to give another batch of the desired product (271 mg, 15%) as a white solid.

1. washwashed with aqueous 1M KHSO4 (3×20 mL), aqueous saturated NaHCO3 (3×20 mL) and brine (2×20 mL)
2. custombefore drying on Na2SO4 and concentration in vacuo
3. customto give an oil
4. dissolutionThe product was dissolved
5. waitleft
6. temperatureto cool for 16 h
7. customA solid had formed which
8. filtrationwas filtered off
9. washwashed with i-Pr2O (2×5 mL)
10. customto give a light yellow solid
11. custompurified

ORD record

ord-ad4cd88d998440f582a2ca43d06015a1

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09302988B2