Sodium Hydroxide → HCID 67975410, compound

HRID 623872Notes

Reaction equation

HRID 623872 reaction equation
[CH3:1][C:2]([CH3:29])([CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[NH:21][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:23][N:24]=3)=[CH:16][N:15]=2)=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4].[OH-].[Na+:31]>O1CCCC1>[CH3:1][C:2]([CH3:29])([CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[NH:21][C:22]([C:25]([F:28])([F:26])[F:27])=[CH:23][N:24]=3)=[CH:16][N:15]=2)=[CH:10][CH:9]=1)[C:3]([O-:5])=[O:4].[Na+:31]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57410854HCID 57410854, compound

Product 1

HCID 67975410HCID 67975410, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In tetrahydrofuran (2.5 mL) was dissolved 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)propanoic acid (250 mg), 10M aqueous sodium hydroxide solution (65 μL) was added to the solution dividing into several times, and the mixture was stirred at room temperature overnight. The precipitate was collected by filtration, washed with tetrahydrofuran (1 mL), and dried at 40° C. under reduced pressure to obtain sodium 2,2-dimethyl-3-(4-{5-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-2-yl}phenoxy)propanoate (216 mg).

Workup

  1. additionwas added to the solution dividing into several times
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with tetrahydrofuran (1 mL)
  4. customdried at 40° C. under reduced pressure

Sources & evidence

ORD record
ord-6d6dc192928b42c89fa5812e32a2c421
Source dataset
uspto-grants-2016_04
Patent number
US09302996B2

Reaction notes

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