Potassium Hydroxide → HCID 178450096, compound

HRID 623901Notes

Reaction equation

HRID 623901 reaction equation
[CH3:1][C:2]([CH3:29])([CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[NH:21][CH:22]=[C:23]([C:25]([F:28])([F:27])[F:26])[N:24]=3)=[CH:16][N:15]=2)=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4].[OH-].[K+:31]>O1CCCC1>[CH3:1][C:2]([CH3:29])([CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[NH:21][CH:22]=[C:23]([C:25]([F:28])([F:26])[F:27])[N:24]=3)=[CH:16][N:15]=2)=[CH:12][CH:13]=1)[C:3]([O-:5])=[O:4].[K+:31]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178450095HCID 178450095, compound

Product 1

HCID 178450096HCID 178450096, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In tetrahydrofuran (10 mL) was suspended 2,2-dimethyl-3-[4-[5-[4-(trifluoromethyl)-1H-imidazol-2-yl]-2-pyridyl]phenoxy]propanoic acid (1001 mg), and the mixture was stirred at room temperature for 30 minutes. 10M aqueous potassium hydroxide solution (0.25 mL) was added dropwise to the mixture, and the mixture was stirred at room temperature for 2 hours. The precipitated solid was collected by filtration, washed with tetrahydrofuran, and dried under reduced pressure to obtain potassium 2,2-dimethyl-3-[4-[5-[4-(trifluoromethyl)-1H-imidazol-2-yl]-2-pyridyl]phenoxy]propanoate (995 mg).

Workup

  1. stirringthe mixture was stirred at room temperature for 2 hours
  2. filtrationThe precipitated solid was collected by filtration
  3. washwashed with tetrahydrofuran
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-4a09057005f042babb874b1b905c16fa
Source dataset
uspto-grants-2016_04
Patent number
US09302996B2

Reaction notes

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