Tert-butyl 3-hydroxy-2,2-dimethylpropanoate → Tert-butyl 3-[(5-chloropyrazin-2-yl)oxy]-2,2-dimethylpropanoate

HRID 623939Notes

Reaction equation

HRID 623939 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]([OH:8])=[N:6][CH:7]=1.O[CH2:10][C:11]([CH3:20])([CH3:19])[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([O:8][CH2:10][C:11]([CH3:20])([CH3:19])[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 54272639Tert-butyl 3-hydroxy-2,2-dimethylpropanoateHCID 178516772HCID 178516772, compound

Product 1

HCID 86698186Tert-butyl 3-[(5-chloropyrazin-2-yl)oxy]-2,2-dimethylpropanoateYield 84.2%

Procedure

By using 5-chloropyrazin-2-ol (700 mg) and tert-butyl hydroxypivalate (1402 mg), the procedure was carried out in the same manner as in Example 1-1) to obtain tert-butyl 3-[(5-chloropyrazin-2-yl)oxy]-2,2-dimethylpropanoate (1294.5 mg).

Sources & evidence

ORD record
ord-54c06b1614b54d93b0733a35754b93eb
Source dataset
uspto-grants-2016_04
Patent number
US09302996B2

Reaction notes

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