HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623967Generated: October 29, 2026
6-Bromo-4-hydroxy-3-phenoxyquinolin-2(1H)-one → 6-Bromo-N,N-diethyl-3-phenoxy-4-(trifluoromethyl)quinolin-2-amine
https://huagongshe.com/reaction/623967
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 6-Bromo-4-hydroxy-3-phenoxyquinolin-2(1H)-one | HCID 86715444 | — |
| Reactant | 6-Bromo-2-chloro-3-phenoxy-4-(trifluoromethyl)quinoline | HCID 86715452 | — |
| Product | 6-Bromo-N,N-diethyl-3-phenoxy-4-(trifluoromethyl)quinolin-2-amine | HCID 86715453 | — |
Reaction Steps
The title compound was prepared using 6-bromo-2-chloro-3-phenoxy-4-(trifluoromethyl)quinoline (Intermediate 8, step b) in place of 6-bromo-2,4-dichloro-3-phenoxyquinoline (Intermediate 5, step c) according to the procedure described in Intermediate 5, step d except the reaction mixture was heated at 100° C. under reflux condenser for 2.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303015B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-7fa3975b7116466a9fcbda1a187a624b |
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| Source note | uspto-grants-2016_04 |
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