HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylaniline → 6-Bromo-4-hydroxy-3-(methyl(phenyl)amino)quinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylaniline | HCID 7515 | — |
| Reactant | (6-Bromo-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)(phenyl) iodoniumtrifluoromethane sulfonate | HCID 86715456 | — |
| Product | 6-Bromo-4-hydroxy-3-(methyl(phenyl)amino)quinolin-2(1H)-one | HCID 86715459 | — |
Reaction Steps
The title compound was prepared using N-methylaniline in place of aniline according to the procedure of Intermediate 11, step c except the crude solid was purified by flash column chromatography (silica gel, 50% EtOAc-Heptane), affording the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303015B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-f9f80428153e450e8e3e3d69be3c9b1e |
| Source note | uspto-grants-2016_04 |