Pyridine → Tert-butyl 5-carbamoyl-2-azatricyclo[3.3.1.13,7]decane-2-carboxylate

A 50 mL RB flask fitted with magnetic stirrer was charged with 5 mL of acetonitrile and 2-(tert-butoxycarbonyl)-2-azatricyclo[3.3.1.13,7]decane-5-carboxylic acid, Intermediate-10 (0.16 g, 0.56 mmol). Under N2 atm, pyridine (60 mg, 0.6 mmol) and Boc-anhydride (0.148 g, 0.6 mmol) was added to the reaction mixture and was stirred for 1 hr. After 1 hr, ammonium bicarbonate solid (75 mg, 0.9 mmol) was added and the reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction (reaction was monitored by TLC), reaction mixture was concentrated under vacuum. The resulted crude material was extracted with ethyl acetate (25 ml×3). The organic layer was washed with ammonium chloride solution and saturated sodium bi carbonate solution. It was then dried over anhydrous sodium sulfate and concentrated to give Intermediate-11, as an oily mass (0.14 g, yield=87%).

1. customA 50 mL RB flask fitted with magnetic stirrer
2. waitAfter 1 hr
3. stirringthe reaction mixture was stirred at room temperature for 12 hours
4. customAfter completion of the reaction (reaction was monitored by TLC), reaction mixture
5. concentrationwas concentrated under vacuum
6. customThe resulted crude material
7. extractionwas extracted with ethyl acetate (25 ml×3)
8. washThe organic layer was washed with ammonium chloride solution and saturated sodium bi carbonate solution
9. dry with materialIt was then dried over anhydrous sodium sulfate
10. concentrationconcentrated
11. customto give Intermediate-11

ORD record

ord-6dc5023c481a4648984b96629fca51c0

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09303016B2