Dichloromethane → Tert-butyl 5-cyano-2-azatricyclo[3.3.1.13,7]decane-2-carboxylate
Reaction equation
C(Cl)Cl.[C:4]([C:7]12[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][CH:9]([N:10]3[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:8]1)[CH2:14]2)(=O)[NH2:5].C(N(CC)CC)C.FC(F)(F)C(OC(=O)C(F)(F)F)=O>CCOC(C)=O>[C:4]([C:7]12[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][CH:9]([N:10]3[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:8]1)[CH2:14]2)#[N:5]Participants
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A 50 mL RB flask fitted with magnetic stirrer was charged with 5 mL of DCM and tert-butyl 5-carbamoyl-2-azatricyclo[3.3.1.13,7]decane-2-carboxylate, Intermediate-11 (0.8 g, 2.8 mmol). Under N2 atm, triethyl amine (1.15 g, 11.4 mmol) and trifluoroacetic anhydride (2.4 g, 11.4 mmol) was added and stirred for 6 hr. After completion of the reaction (reaction was monitored by TLC), reaction mixture was quenched with KHSO4 solution and extracted with DCM (50 ml×3). The organic layer was washed with saturated sodium bi carbonate solution followed by brine solution. Finally the reaction mixture was dried over anhydrous sodium sulfate and concentrated to give crude Intermediate-13, which was subjected to column chromatogram (10% EtOAc in PE) as a off-white solid (0.5 g, yield=70%).
Workup
- customA 50 mL RB flask fitted with magnetic stirrer
- customAfter completion of the reaction (reaction was monitored by TLC), reaction mixture
- customwas quenched with KHSO4 solution
- extractionextracted with DCM (50 ml×3)
- washThe organic layer was washed with saturated sodium bi carbonate solution
- dry with materialFinally the reaction mixture was dried over anhydrous sodium sulfate
- concentrationconcentrated
- customto give crude Intermediate-13, which
Sources & evidence
- ORD record
- ord-7702bddefc004d3886d4ca6cc06a72ad
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09303016B2
Reaction notes
Loading…