5-Fluoroindole → 3-(2-bromoethyl)-5-fluoro-1H-indole

HRID 624054Notes

Reaction equation

HRID 624054 reaction equation
[Br:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10](OC)[CH:11]=2)[NH:6][CH:5]=1.[F:15]C1C=C2C(=CC=1)NC=C2>>[Br:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:15])[CH:11]=2)[NH:6][CH:5]=1

Participants

3

Reactant 2

HCID 678615-FluoroindoleHCID 111078683-(2-bromoethyl)-5-methoxy-1H-indole

Product 1

HCID 112072263-(2-bromoethyl)-5-fluoro-1H-indole

Procedure

The title compound was synthesized according to above mentioned procedure for 3-(2-bromoethyl)-5-methoxy-1H-indole, starting with 5-fluoroindole yielding a brown oil which was stored in the freezer. LC-MS conditions B: tR=0.82 min, [M(81Br)+MeCN+H]+=244.07.

Sources & evidence

ORD record
ord-8f8a52b730eb475cb6355e44fb91ae6c
Source dataset
uspto-grants-2016_04
Patent number
US09303023B2

Reaction notes

Loading…