反应详情

温度

0 °C

Isoindoline (1.693 ml, 14.47 mmol) was dissolved in tetrahydrofuran (20 ml) and cooled to 0° C.; and methyl 4-isocyanatobenzoate (2.18 g, 12.06 mmol) was added by syringe and the resulting mixture was warmed to ambient temperature, and then stirred overnight. The solution was concentrated to a slurry, diluted with ether, and filtered to provide the title compound.

1. temperaturethe resulting mixture was warmed to ambient temperature
2. concentrationThe solution was concentrated to a slurry
3. additiondiluted with ether
4. filtrationfiltered