Hydrazine hydrate (1:1) → HCID 68750341, compound

HRID 624157Notes

Reaction equation

HRID 624157 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[C:14](O)=[O:15])=O)=[CH:4][CH:3]=1.O.[NH2:20][NH2:21]>C(O)C>[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]2[C:8]3[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=3[C:14](=[O:15])[NH:21][N:20]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 68750696HCID 68750696, compound

Product 1

HCID 68750341HCID 68750341, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.3 g of 2-(4-amino-benzoyl)-cyclohex-1-enecarboxylic acid (42 mmol) were dissolved in 45 mL ethanol, 2.7 g (54 mmol) hydrazine hydrate was added and the mixture was heated under reflux for 30 hours. Precipitation of the product already started several hours after heating. After cooling in the refrigerator overnight the precipitated product was filtered and washed with cold ethanol.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 hours
  3. customPrecipitation of the product already started several hours
  4. temperatureafter heating
  5. temperatureAfter cooling in the refrigerator overnight the precipitated product
  6. filtrationwas filtered
  7. washwashed with cold ethanol

Sources & evidence

ORD record
ord-966dbe9931bb46c0835769b3c753dac0
Source dataset
uspto-grants-2016_04
Patent number
US09302989B2

Reaction notes

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