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Benzyl N-[(oxolan-3-yl)methyl]carbamate → (R)-benzyl (tetrahydrofuran-3-yl)methylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl N-[(oxolan-3-yl)methyl]carbamate | HCID 86665085 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (R)-benzyl (tetrahydrofuran-3-yl)methylcarbamate | HCID 86665083 | — |
| 生成物 | (S)-benzyl (tetrahydrofuran-3-yl)methylcarbamate | HCID 86665084 | — |
反応手順
A racemic mixture of benzyl (tetrahydrofuran-3-yl)methylcarbamate was dissolved in tetrahydrofuran and separated by liquid chromatography with a Chiralpak IC 2.5 cm ID×25 cm, 20 micron column, eleuting with hexane/tetrahydrofuran/isopropanol (85/10/5), to provide (R)-benzyl (tetrahydrofuran-3-yl)methylcarbamate and (S)-benzyl (tetrahydrofuran-3-yl)methylcarbamate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09302989B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-4f13e52836854f93b89bbe6fbb083615 |
| 出典メモ | uspto-grants-2016_04 |