反应详情

温度

90 °C

Claisen's alkali (potassium hydroxide, 12.7 g in 9 ml water and 33 ml methanol) was added to N-(4-(3-(1,1-dimethylethylsulfinamido)oxetan-3-yl)phenyl)acetamide (300 mg, 0.966 mmol) and the reaction was stirred at 90° C. for 2 hours. The mixture was cooled to room temperature when water and ethyl acetate were added. The aqueous layer was extracted twice with ethyl acetate and the combined organics were dried with magnesium sulfate, filtered and concentrated under vacuum. The residue was purified by regular phase flash column chromatography to give the title compound.

1. additionwere added
2. extractionThe aqueous layer was extracted twice with ethyl acetate
3. dry with materialthe combined organics were dried with magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated under vacuum
6. customThe residue was purified by regular phase flash column chromatography