Hydrochloric Acid → HCID 68749179, compound

HRID 624276Notes

Reaction equation

HRID 624276 reaction equation
CC(C)(S([NH:6][C:7]1([C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18]([N:20]3[CH2:28][C:27]4[CH:26]=[CH:25][N:24]=[CH:23][C:22]=4[CH2:21]3)=[O:19])=[CH:13][CH:12]=2)[CH2:10][O:9][CH2:8]1)=O)C.Cl.O1CCOCC1>CO>[NH2:6][C:7]1([C:11]2[CH:12]=[CH:13][C:14]([NH:17][C:18]([N:20]3[CH2:28][C:27]4[CH:26]=[CH:25][N:24]=[CH:23][C:22]=4[CH2:21]3)=[O:19])=[CH:15][CH:16]=2)[CH2:10][O:9][CH2:8]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 68753478HCID 68753478, compound

Product 1

HCID 68749179HCID 68749179, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a 20 mL vial was added N-(4-(3-(1,1-dimethylethylsulfinamido)oxetan-3-yl)phenyl)-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxamide (253 mg, 0.610 mmol) and methanol (6.1 ml). 4N HCl in dioxane (229 μl, 0.916 mmol) was added and the reaction was stirred for 2 hours. The mixture was concentrated under vacuum to give the title compound which was used without further purification.

Workup

  1. concentrationThe mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-a0701b55bd854664833240a5eeea32a4
Source dataset
uspto-grants-2016_04
Patent number
US09302989B2

Reaction notes

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