反应详情

A solution of 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid (1 g, 4.65 mmol) in tetrahydrofuran (5 ml) was cooled to 0° C. and treated with borane tetrahydrofuran complex (7.00 ml, 7 mmol) dropwise by syringe. After 1 hour at 0° C. the solution was allowed to warm to room temperature and stirred overnight and then it was quenched with 20 ml of 1M aqueous NaOH. The separated aqueous layer was extracted with ether (2×15 ml), dried with magnesium sulfate, filtered and concentrated to give the title compound which was used without purification.

1. additiontreated with borane tetrahydrofuran complex (7.00 ml, 7 mmol) dropwise by syringe
2. customit was quenched with 20 ml of 1M aqueous NaOH
3. extractionThe separated aqueous layer was extracted with ether (2×15 ml)
4. dry with materialdried with magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated