Hydrochloric Acid → HCID 78121192, compound

Participants

Reaction Steps

This was converted to the (2R,5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]-nonan-6-one hydrochloride (E1) by addition of HCl (1 M in diethyl ether) to a DCM solution of the free base. Evaporation followed by further drying under reduced pressure gave an amber solid. The latter was further dried under reduced pressure at 40° C. to give the title compound in 58% yield;

Provenance & Evidence