Hydrochloric Acid → HCID 78121192, compound

HRID 624305Notes

Reaction equation

HRID 624305 reaction equation
[ClH:1].[CH3:2][N:3]1[CH2:28][CH2:27][C@:5]2([NH:9][C@@H:8]([C:10]3[CH:15]=[C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]([F:26])([F:25])[F:24])[CH:17]=4)[CH:13]=[CH:12][N:11]=3)[CH2:7][CH2:6]2)[C:4]1=[O:29].Cl>C(Cl)Cl>[ClH:1].[CH3:2][N:3]1[CH2:28][CH2:27][C:5]2([NH:9][CH:8]([C:10]3[CH:15]=[C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]([F:25])([F:26])[F:24])[CH:17]=4)[CH:13]=[CH:12][N:11]=3)[CH2:7][CH2:6]2)[C:4]1=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71582999HCID 71582999, compound

Product 1

HCID 78121192HCID 78121192, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This was converted to the (2R,5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]-nonan-6-one hydrochloride (E1) by addition of HCl (1 M in diethyl ether) to a DCM solution of the free base. Evaporation followed by further drying under reduced pressure gave an amber solid. The latter was further dried under reduced pressure at 40° C. to give the title compound in 58% yield;

Workup

  1. customEvaporation
  2. customby further drying under reduced pressure
  3. customgave an amber solid
  4. customThe latter was further dried under reduced pressure at 40° C.

Sources & evidence

ORD record
ord-780b55e364a34473980e8e6157a95800
Source dataset
uspto-grants-2016_04
Patent number
US09303032B2

Reaction notes

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