4-Chloro-3-nitrobenzenesulfonamide → 4-(1-Isopropylpiperidin-4-ylamino)-3-nitrobenzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-chloro-3-nitrobenzenesulfonamide (1.664 g) triethylamine (2 mL) and 1-isopropylpiperidin-4-amine (1 g) in dioxane (10 mL) was stirred for 16 hours at 90° C. The reaction mixture was cooled to room temperature and the solid material was filtered off. The solid material was washed with 20% methanol/dichloromethane, and the mixture was dried under vacuum, to provide the product.

Provenance & Evidence