Hydrochloric Acid → HCID 67226071, compound

HRID 624352Notes

Reaction equation

HRID 624352 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14][N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:22]=[CH:23][C:24]([C:54]([O:56][CH3:57])=[O:55])=[C:25]([CH:53]=3)[O:26][C:27]3[CH:28]=[C:29]4[C:33](=[CH:34][CH:35]=3)[N:32](C(OC(C)(C)C)=O)[CH:31]=[C:30]4[CH2:43][CH2:44][C:45]([N:47]3[CH2:52][CH2:51][O:50][CH2:49][CH2:48]3)=[O:46])[CH2:17][CH2:16]2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[CH2:14][N:15]2[CH2:16][CH2:17][N:18]([C:21]3[CH:22]=[CH:23][C:24]([C:54]([O:56][CH3:57])=[O:55])=[C:25]([O:26][C:27]4[CH:28]=[C:29]5[C:33](=[CH:34][CH:35]=4)[NH:32][CH:31]=[C:30]5[CH2:43][CH2:44][C:45]([N:47]4[CH2:52][CH2:51][O:50][CH2:49][CH2:48]4)=[O:46])[CH:53]=3)[CH2:19][CH2:20]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67227766HCID 67227766, compound

Product 1

HCID 67226071HCID 67226071, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of EXAMPLE 70C (300 mg) in dioxane (2 mL) was treated with concentrated aqueous hydrogen chloride (0.378 mL) and stirred at room temperature overnight. The solution was concentrated and the residue was used for the next step without further purification.

Workup

  1. concentrationThe solution was concentrated
  2. customthe residue was used for the next step without further purification

Sources & evidence

ORD record
ord-9544d256a09e47df9d4ae18558e58bbe
Source dataset
uspto-grants-2016_04
Patent number
US09303025B2

Reaction notes

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