反应详情

温度

90 °C

Tert-butyl 4-aminopiperidine-1-carboxylate (8.63 g) was dissolved in 1,4-dioxane (250 mL), and 4-chloro-3-nitrobenzenesulfonamide (6.00 g) was added followed by triethylamine (10.60 mL). The solution was heated at 90° C. for 20 hours and then cooled. The solvent was removed under vacuum, and the material purified by flash column chromatography on silica gel using 50% ethyl acetate in hexanes, increasing to 100% ethyl acetate and increasing further to 20% methanol in dichloromethane.

1. temperaturecooled
2. customThe solvent was removed under vacuum
3. customthe material purified by flash column chromatography on silica gel using 50% ethyl acetate in hexanes
4. temperatureincreasing to 100% ethyl acetate
5. temperatureincreasing further to 20% methanol in dichloromethane