反应详情

A solution of 2,3-difluoro-4-nitroanisole (10 g) in 48% HBr (60 mL) and 30% HBr in acetic acid (30 mL) was stirred at 120° C. overnight. The mixture was cooled to room temperature and extracted with ethyl acetate (3×200 mL) and the combined extracts were washed with brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the product.

1. extractionextracted with ethyl acetate (3×200 mL)
2. washthe combined extracts were washed with brine
3. dry with materialdried over Na2SO4
4. filtrationFiltration and evaporation of the solvent
5. customgave the product