Hydrochloric Acid → 1-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

HRID 624415Notes

Reaction equation

HRID 624415 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:20]>CCOCC>[ClH:20].[ClH:20].[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46785855HCID 46785855, compound

Product 1

HCID 441204811-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of EXAMPLE 336A (3.92 g) in ether was added HCl (25 mL, 2M in ether) and the reaction mixture was stirred for 16 hours at room temperature. The solid product was filtered off, dried and used in next step without further purification.

Workup

  1. filtrationThe solid product was filtered off
  2. customdried
  3. customused in next step without further purification

Sources & evidence

ORD record
ord-138b7f02e2b34323a9cfec14d6691810
Source dataset
uspto-grants-2016_04
Patent number
US09303025B2

Reaction notes

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