反应详情

To a solution of EXAMPLE 342B (2.59 g) in tetrahydrofuran (40 mL) was added tetraammonium fluoride (1M in tetrahydrofuran, 21.03 mL). The solution was mixed at room temperature for two hours. The solvent was removed under vacuum, the residue was taken up in ethyl acetate, and the solution was vacuum filtered over a pad of silica gel. The filtrate was concentrated and purified by flash column chromatography on silica gel using 35% ethyl acetate in hexanes.

1. additionThe solution was mixed at room temperature for two hours
2. customThe solvent was removed under vacuum
3. filtrationfiltered over a pad of silica gel
4. concentrationThe filtrate was concentrated
5. custompurified by flash column chromatography on silica gel using 35% ethyl acetate in hexanes