Trifluoroacetic acid → HCID 178511287, compound

HRID 624448Notes

Reaction equation

HRID 624448 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH2:8][NH:9]C(=O)OC(C)(C)C)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>ClCCl>[NH2:9][CH2:8][C@H:5]1[CH2:6][CH2:7][C@H:2]([OH:1])[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453650HCID 178453650, compound

Product 1

HCID 178511287HCID 178511287, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl trans-(4-hydroxycyclohexyl)methylcarbamate (1 g) in dichloromethane (10 ml) was treated with trifluoroacetic acid (10 ml) at 0° C. for two hours. The reaction mixture was concentrated and the residue was dried under vacuum to provide the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-5cb47aa7ef8144958e6711f8362b81b5
Source dataset
uspto-grants-2016_04
Patent number
US09303025B2

Reaction notes

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