Trifluoroacetic acid → HCID 178511076, compound

HRID 624461Notes

Reaction equation

HRID 624461 reaction equation
C(OC(=O)[NH:7][CH2:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][C:16]#[N:17])[CH2:11][CH2:10]1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][CH2:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][C:16]#[N:17])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453593HCID 178453593, compound

Product 1

HCID 178511076HCID 178511076, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl(trans-4-(cyanomethyl)cyclohexyl)methylcarbamate (500 mg) in dichloromethane (5 mL) was slowly added trifluoroacetic acid (3 mL) at 0° C. The mixture was warmed to room temperature, stirred for 1 hour and concentrated. The residue was dried under vacuum to provide the title compound.

Workup

  1. customat 0° C
  2. concentrationconcentrated
  3. customThe residue was dried under vacuum

Sources & evidence

ORD record
ord-5f3385120a0f4ae2bc5565aaa3d56ea2
Source dataset
uspto-grants-2016_04
Patent number
US09303025B2

Reaction notes

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